• Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma 

      Wirsing, Anna Maria; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-23)
      <p><i>Background -</i>Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate ...
    • Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study 

      Bjerkli, Inger-Heidi; Jetlund, Olav; Karevold, Gunnhild; Karlsdottir, Åsa; Jaatun, Ellen A. Andreassen; Uhlin-Hansen, Lars; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-16)
      <i>Objectives</i> - Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization is important to follow for future trends. The aim of this retrospective study was to present a large cohort of primary oral cavity squamous cell carcinoma from all four health regions of Norway, with descriptive clinicopathological characteristics and five-year survival ...
    • Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study 

      Rikardsen, Oddveig G; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Friedman Score in Relation to Compliance and Treatment Response in Nonsevere Obstructive Sleep Apnea 

      Berg, Lars Martin; Ankjell, Torun Karina Solheim; Sun, Yi-Qian; Trovik, Tordis A; Sjögren, Anders; Rikardsen, Oddveig G; Moen, Ketil; Hellem, Sølve; Bugten, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
      Nonsevere obstructive sleep apnea (OSA) is most often treated with a continuous positive airway pressure (CPAP) device or a mandibular advancement splint (MAS). However, patient compliance with these treatments is difficult to predict. Improvement in apnea-hypopnea index (AHI) is also somewhat unpredictable in MAS treatment. In this study, we investigated the association between Friedman tongue ...
    • Health-related quality of life and sleep quality after 12 months of treatment in non-severe obstructive sleep apnea: A randomized clinical trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints 

      Berg, Lars Martin; Ankjell, Torun Karina Solheim; Sun, Yi-Qian; Trovik, Tordis A; Rikardsen, Oddveig G; Sjögren, Anders; Moen, Ketil; Hellem, Sølve; Bugten, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-01)
      In this randomized controlled trial, patients with non-severe obstructive sleep apnea (OSA) were treated with continuous positive airway pressure (CPAP) or a twin block mandibular advancement splint (MAS). The primary objective was to compare how CPAP and MAS treatments change the health-related quality of life (HRQoL) and self-reported sleep quality of patients after 12 months of treatment. In ...
    • Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma 

      Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita; Vallenari, Evan Michael; Shahdafar, Aboulghassem; Pun, Chin B.; Gautam, Dej K.; Uhlin-Hansen, Lars; Rikardsen, Oddveig G; Johannessen, Anne Christine; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-23)
      <i>Background</i> - We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in OSCC.<p><p> <i>Methods</i> - S100A14 expression was examined in 170 OSCCs from Norwegian and Nepalese populations using immunohistochemistry. Pro‐differentiation function ...
    • Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma 

      Rikardsen, Oddveig G; Magnussen, Synnøve; Svineng, Gunbjørg; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-26)
      <p>Background: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need ...
    • Presence of tumour high-endothelial venules is an independent positive prognostic factor and stratifies patients with advanced-stage oral squamous cell carcinoma 

      Wirsing, Anna Maria; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-17)
      Background: Staging of oral squamous cell carcinoma is based on the TNM system, which has been deemed insufficient for prognostic purposes. Hence, better prognostic tools are needed to reflect the biological diversity of these cancers. Previously, high numbers of specialized blood vessels called high-endothelial venules have been reported to be associated with prolonged survival in patients with ...
    • Prognostic markers in oral squamous cell carcinoma 

      Rikardsen, Oddveig G (Doctoral thesis; Doktorgradsavhandling, 2014-06-20)
      Avhandlingen er basert på 5 artikler. Vi har retrospektivt innhentet klinisk informasjon om 133 pasienter diagnostisert med cancer i munnhulen ved UNN i perioden 1986-2001, og laget Tissue Micro Arrays (TMA) av tumorvev fra de respektive pasientenes svulster. Den første artikkelen er en epidemiologisk beskrivelse av materialet. Artikkel 2 og 3 omfatter ulike potensielle prognostiske markører for ...
    • Self-reported sleep quality with mandibular advancement device or continuous positive airway pressure: A randomized clinical trial on patients with mild and moderate obstructive sleep apnea 

      Berg, Lars Martin; Ankjell, Torun Karina Solheim; Trovik, Tordis A; Sjögren, Anders; Rikardsen, Oddveig G; Moen, Ketil; Sun, Yi-Qian; Bugten, Vegard (Journal article; Tidsskriftartikkel, 2020)
      <i>Study</i> - objectives To compare self-reported sleep quality, treatment compliance and respiratory event index (REI) after 4 months of treatment with mandibular advancement device (MAD) or continuous positive airway pressure (CPAP) in mild and moderate obstructive sleep apnea (OSA). <p> <p><i>Methods</i> - 104 patients with mild or moderate OSA were randomly allocated to MAD or CPAP treatment, ...
    • Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts 

      Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Steigen, sonja eriksson; Ljones, Hilde; Grenman, Reidar; Kanapathippillai, Premasany; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
    • Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC) 

      Magnussen, Synnøve; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort 

      Wirsing, Anna Maria; Bjerkli, Inger-Heidi; Steigen, Sonja Eriksson; Rikardsen, Oddveig G; Norvoll Magnussen, Synnøve; Hegge, Beate; Seppola, Marit; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-14)
      The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral ...